Surp and g-patch domain-containing protein 14

Thus, it is likely that the surp modules within a single protein are not functionally homologous and perhaps may bind to distinct proteins or to two distinct sites of a single interacting protein. An additional 14 spliceosomeassociated proteins were detected below the cutoff used for the data in. Mammalian splicing factor sf1 interacts with surp domains of. Sugp2 surp and g patch domain containing 2 house mouse gene id.

Gene ontology go annotations related to this gene include nucleic acid binding. Putative splicing factor, arginineserinerich 14 is a protein that in humans is encoded by the sfrs14 gene references. Stress granules and processing bodies share rna and protein components, both appear under stress, and can physically associate with one another. Gpatch2 gene genecards gptc2 protein gptc2 antibody. Q9ui333 isoform 3 of sodium channel protein type 11 subunit alpha 22 0 1. Predicted intracellular proteins intracellular proteins predicted by mdm and mdsec mapped to nextprot nextprot evidence at protein level protein evidence peptideatlas show all. As of 2018, of the 660 proteins identified as localizing to stress granules, 11% also have been identified as processing bodylocalized proteins see below. Recently, it was reported that hotspot mutations in sf3b1 specifically disrupted the interaction with the spliceosomal protein, surp and the gpatch domaincontaining 1 sugp1, without the. Hect and rld domain containing e3 ubiquitin protein ligase 2. Sugp2 surp and gpatch domaincontaining protein 2 homo. Ipr040169 surp and gpatch domaincontaining protein 12. Diseases associated with gpatch2 include lymphogranuloma venereum and granuloma inguinale. The function of two helicases from this family, prp2 and prp43, is regulated by protein partners containing a gpatch domain.

Sugp2 surp and gpatch domain containing 2, authors. The resulting frameshift leads to sickle cell anemia. Sugp1 surp and gpatch domain containing 1 is a protein coding gene. Sugp2, surp and gpatch domain containing 2 vertebrate orthologs 8 human ortholog sugp2, surp and gpatch domain containing 2. Sfrs14 encodes a deduced 1,083amino acid protein with an estimated molecular mass of 120. Protein protein interactions application by cisbio. Several groups of gpatch containing proteins are conserved in animals, plants and fungi. Imagine a global collaborative knowledge base for original thoughts. Sugp1 surp and gpatch domain containing 1, authors.

Alternative names arginineserinerichsplicing factor 14. Loc114459751 surp and gpatch domaincontaining protein 1like bluntsnouted clingfish gene id. Atlas of genetics and cytogenetics in oncology and haematology home genes leukemias solid tumors cancerprone deep insight case reports journals portal teaching. Rbm10, rna binding motif protein 10, s11, dxs8237e, kiaa0122, zranb5. Gpatch domain containing gpatch gene family hugo gene. Sugp2 surp and gpatch domain containing 2 northern. Both sf4 and sfrs14 contain 2 surp motifs and a single gpatch domain in. Loc103330493 surp and gpatch domaincontaining protein 1like protein japanese apricot gene id. The deduced fulllength protein contains 1,445 amino acids. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool. The gpatch is a glycinerich domain discovered by sequence alignment, involved in protein protein and protein nucleic acid interaction. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Search thousands of articles and collaborate with scientists around the globe. Insul8 qtl report rattus norvegicus rat genome database.

Probable component of an e3 ubiquitin protein ligase complex, in which it may act as a substrate recognition subunit. Sensing of alzheimers disease and multiple sclerosis using. Produktubersicht splicing factor, arginineserinerich 14. General description splicing factor 4 surp and g patch domain containing 1 sf4, rbp, sugp1 is closely related to sfrs14 arginineserinerich splicing factor 4 which is a potential normalization protein for gene expression studies in hcv. Hect and rld domain containing e3 ubiquitin protein ligase 4. Gpatch domaincontaining protein 2, arginineserinerichsplicing factor 14. It has a domain involved in rna processing and modification, a c2h2type zinc finger, an rgd motif, a nuclear localization signal, and sites for amidation, myristoylation, lipidation, nglycosylation, glycosaminoglycan attachment, and phosphorylation. Loc114459751 surp and gpatch domaincontaining protein 1. Sensing of alzheimers disease and multiple sclerosis using nanobio interfaces. Sugp1 surp and gpatch domaincontaining protein 1 mus. Atlas of genetics and cytogenetics in oncology and haematology home genes leukemias solid tumors cancerprone deep. Among its related pathways are gene expression and mrna splicing major pathway. Protein annotations for g patch domaincontaining protein. More data hpa041557 rabbit anti surp and gpatch domain containing 2 antibody.

This gene encodes a member of the arginineserinerich family of splicing factors. Sf4 and sfrs14, two related putative splicing factors on. Sugp2, surp and gpatch domain containing 2, sfrs14, kiaa0365, 19p. Surp and gpatch domaincontaining protein 2, splicing factor, arginineserinerich 14, splicing factor, arginineserinerich 14. Sorted by availability of experimental interaction data e. Wikigenes sugp1 surp and g patch domain containing 1.

Tested in western blot wb and immunoprecipitation ip applications. Surp and gpatch domaincontaining protein 1 recommended applications product description stable isotopelabeled standard for absolute protein quantification of sugp1. Protein name surp and gpatch domaincontaining protein 2. Surp and g patch domain containing 2 sugp2 antibody. Splicing factor, arginineserinerich 14 sfrs14 antibodies.

Surp and gpatch domaincontaining protein 1 gene id species. Mammalian splicing factor sf1 interacts with surp domains. Sugp2 protein expression summary the human protein atlas. Sugp2 surp and g patch domain containing 2 is a protein coding gene. Browse our splicing factor, arginineserinerich 14 proteins. Validated for immunofluorescence, immunohistochemistry and western blot. Omim entry 614396 gpatch domaincontaining protein 8. Sugp1 is a novel regulator of cholesterol metabolism human. Sugp1 surp and gpatch domaincontaining protein 1 homo. Surp and gpatch domaincontaining protein 2, arginineserinerichsplicing factor 14, putative splicing factor, arginineserinerich 14, serineargininerich splicing factor 14. Sugp2 surp and gpatch domain containing 2 is a protein coding gene. Tbl2 transducin betalike protein 2 in homo sapiens. Both sf4 and sfrs14 contain 2 surp motifs and a single gpatch domain in their c termini.

Gpatch2 gpatch domain containing 2 is a protein coding gene. Sf4 and sfrs14, two related putative splicing factors on human chromosome 19p. Promotes the utilization of a cryptic splice site created by the beta110 mutation in the hbb gene. Gene ontology go annotations related to this gene include nucleic acid binding and rna binding. Alternative names arginine serinerichsplicing factor 14. Sugp2 surp and g patch domain containing 2 synonyms. Sugp2 surp and g patch domain containing 2 house mouse. Complete information for sugp1 gene protein coding, surp and gpatch domain containing 1, including. Table1, 1, the u2 snrnpassociated surp motifcontaining protein u2surpsr140 and the a complex component surp and gpatch domaincontaining protein 1 sugp1sf4. Ontomate literature search jbrowse genome browser variant visualizer multiontology enrichment moet geneortholog location finder golf interviewer protein protein interactions phenominer quatitative phenotypes gene annotator olga gene list generator ratmine gviewer genome viewer overgo probe designer acp haplotyper genome scanner. Sfrs14 and sf4 contain gpatch domains at their ctermini. Alternatively spliced transcript variants have been described. Surp and gpatch domaincontaining protein 1like protein.

Antig patch domain and kow motifscontaining protein antibody produced in rabbit, antig patch domaincontaining protein 5 antibody produced in rabbit, anti protein mos2 homolog antibody produced in rabbit, anti protein t54 antibody produced in rabbit. Diseases associated with sugp1 include louping ill and osteogenesis imperfecta, type i. Order us biologicals antisfrs14, ct azide free apc sku. Interpro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. Surp and gpatch domaincontaining protein 2, arginineserinerichsplicing factor 14, putative splicing factor, arginineserinerich 14, serineargininerich splicing factor 14, splicing factor, arginineserinerich 14. Loc103330493 surp and gpatch domaincontaining protein 1. Sfrs14 products available through novus biologicals. Rna helicases from the deahrha family are present in all the processes of rna metabolism.

N metabolically labeled recombinant protein fragment. Group gene id gene protein id tot tp sc tp sc description mass pep kevin. Protein name surp and gpatch domaincontaining protein 2 100% guarantee bethyl guarantees that its products will work under the same conditions stated on the product datasheet. We used affinity purification to isolate spliceosomal complexes associated with either wildtype wt or the hotspot k700e mutant sf3b1. Pdf sugp1 is a novel regulator of cholesterol metabolism. Two additional proteins containing surp domains were found by coip table 1, the u2 snrnpassociated surp motifcontaining protein u2surpsr140 and the a complex component surp and gpatch domaincontaining protein 1 sugp1sf4. Determining the function of the surp motif will be required to investigate this possibility. Surp and gpatch domaincontaining protein 2 mus musculus 118 975. Tm6sf2 is located on chromosome 19 precisely at locus 19p. Rabbit polyclonal antisugp1 antibody against human surp and g patch domain containing 1. Diseasecausing mutations in sf3b1 alter splicing by. Sugp1, surp and gpatch domain containing 1 vertebrate orthologs 10 human ortholog sugp1, surp and gpatch domain containing 1. Sampson and hewitt 2003 also cloned the mouse orthologs.

In some of these proteins the g patch is the only recognisable domain but in most of them it is combined with other domains, which include welldefined rnabinding domains, such as the rrm, dsrbd, surp and r3h. Gene names and symbols associated with splicing factor 4 proteins sf4 surp and gpatch domain containing 1 sugp1 antibody surp and gpatch domain containing 1 sugp1 antibody. Putative splicing factor, arginineserinerich 14 is a protein that in humans is encoded by the. Sfrs14 also contains an arginineserinerich n terminus, suggesting that it is a novel member of the srrelated family of premrna processing factors.